| Tag | Datum | Uhrzeit | Halle | Heim | Gast | Ergebnis |
|---|
| Sa. | 11.09.2021 | 19:30 | Dreifach Sporthalle Miltenberg
| TV Kirchzell | HSC 2000 Coburg II | 30:27 (20:13) |
| Sa. | 18.09.2021 | 19:30 | Main-Kinzig-Halle
| HSG Hanau | HSC 2000 Coburg II | 36:14 (22:6) |
| So. | 26.09.2021 | 16:00 | HUK-COBURG arena
| HSC 2000 Coburg II | HSG Rodgau Nieder-Roden | 23:31 (10:18) |
| Sa. | 02.10.2021 | 19:30 | Sporthalle Dutenhofen
| HSG Dutenhofen-Münchholzhausen II | HSC 2000 Coburg II | 28:24 (15:9) |
| So. | 10.10.2021 | 16:00 | HUK-COBURG arena
| HSC 2000 Coburg II | HC Erlangen II | 16:32 (7:14) |
| Sa. | 16.10.2021 | 19:00 | Großsporthalle im Wesner
| HSG Bieberau-Modau | HSC 2000 Coburg II | 25:19 (13:11) |
| So. | 24.10.2021 | 16:00 | HUK-COBURG arena
| HSC 2000 Coburg II | HSC Bad Neustadt | |
| Sa. | 30.10.2021 | 19:30 | Großsporthalle Gelnhausen
| TV Gelnhausen | HSC 2000 Coburg II | |
| So. | 14.11.2021 | 16:00 | HUK-COBURG arena
| HSC 2000 Coburg II | DJK Sportfreunde Budenheim | |
| Sa. | 20.11.2021 | 19:30 | Schulzentrum Ost
| HaSpo Bayreuth | HSC 2000 Coburg II | |
| So. | 05.12.2021 | 16:00 | HUK-COBURG arena
| HSC 2000 Coburg II | TV Kirchzell | |
| Sa. | 11.12.2021 | 19:00 | HUK-COBURG arena
| HSC 2000 Coburg II | HSG Hanau | |
| Sa. | 15.01.2022 | 19:30 | Sporthalle Nieder-Roden
| HSG Rodgau Nieder-Roden | HSC 2000 Coburg II | |
| Sa. | 22.01.2022 | 19:00 | HUK-COBURG arena
| HSC 2000 Coburg II | HSG Dutenhofen-Münchholzhausen II | |
| Sa. | 29.01.2022 | 19:00 | Karl-Heinz-Hirsemann-Halle
| HC Erlangen II | HSC 2000 Coburg II | |
| So. | 13.02.2022 | 16:00 | HUK-COBURG arena
| HSC 2000 Coburg II | HSG Bieberau-Modau | |
| Sa. | 19.02.2022 | 19:30 | Bgm.-Goebels-Halle
| HSC Bad Neustadt | HSC 2000 Coburg II | |
| So. | 27.02.2022 | 16:00 | HUK-COBURG arena
| HSC 2000 Coburg II | TV Gelnhausen | |
| Sa. | 05.03.2022 | 19:30 | Waldsporthalle Budenheim
| DJK Sportfreunde Budenheim | HSC 2000 Coburg II | |
| So. | 13.03.2021 | 16:00 | HUK-COBURG arena
| HSC 2000 Coburg II | HaSpo Bayreuth | |
